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Australian Institute of Pharmacognosy

The Evidence Synthesis: Decoding Black Cohosh

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8:359 October 2026Plant Evidence Reviews

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Black cohosh (Actaea racemosa, long filed as Cimicifuga racemosa) is widely sold for menopausal hot flushes, and in Australia every oral medicine containing it has to carry a liver warning. This film follows the Institute's draft monograph on the plant, which starts from a simple point: you can't judge a herb's effects or its safety until you know the capsule really holds it.

It covers the three things the monograph checks. First, identity: the rhizome by eye, then under the microscope, then by HPLC fingerprinting, plus the thin-layer chromatography screen for cimifugin, a marker of Asian Cimicifuga species that should never be in authentic material. A TGA survey found 35% of Australian products held other species. Second, the clinical record, graded low certainty, and the gap between the low-dose European extracts used in the trials and the much stronger liquid extracts used in Australian practice. Third, liver safety: why case reports are hard to assess, and Health Canada's finding that some products linked to liver injury held no black cohosh at all.

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